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IVFDaily 2020.06 - Created on 13/02/2020 7:29:21 AM - CPDID=626
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ID Publications Linked Activities
Mortality from infancy to adolescence in singleton children conceived from assisted reproductive techniques versus naturally conceived singletons in S    
8415 (0) Conclusion(s): Singletons conceived through ART had an increased risk of infant mortality from birth up to 1 year of life, predominantly in the early neonatal period and in pregnancies after transfer of frozen and thawed embryos
View childhood mortality/infant mortality/live birth/neonatal mortality/pregnancy/    

IVF-conceived children have somewhat higher mortality risk in their first weeks of life    
8414 (0) Children conceived with assisted reproductive techniques including IVF have a somewhat higher mortality risk during their first weeks of life than children conceived naturally, according to a new study. The researchers link the increased risk to a higher degree of premature births in IVF children and emphasize that the risk of infant mortality is still very small for both groups.
View childhood mortality/infant mortality/live birth/neonatal mortality/pregnancy/    

Metabolic profile of in-vitro derived human embryos is not affected by the mode of fertilization    
8413 (0) In conclusion, the microinjection of spermatozoa into oocytes does not appear to have an impact on subsequent metabolism and viability. Observed differences in amino acid metabolism may be attributed to male factor infertility of the patients rather than the ICSI procedure per se.
View blastocyst/embryo/human/metabolism/icsi/viability/embryo metabolism/amino acid turnover /    

Testosterone Replacement Therapy in Men who Conceived with Intracytoplasmic Sperm Injection - Nationwide Register Study.    
8412 (0) Men who have to utilise powerful techniques, such as ICSI for fathering children, may be at risk for testosterone deficiency. Routine endocrine evaluation of men seeking fertility treatment is hence warranted.
View icsi/icsi fathers/testosterone deficiency/    

Is Embryo Cryopreservation Causing Macrosomia—and What Else?    
8411 (0) Therefore, when considering elective freeze-all policy, in addition to LBR and the risk of ovarian hyperstimulation syndrome, physicians should consider the aforementioned increased FET cycles' pregnancy complications, including LGA/ macrosomia, hypertensive disorders of pregnancy, as well as perinatal mortali
View cryopreservation/frozen-thawed embryo transfer/macrosomia/ pregnancy complications/    

Embryotoxicity testing of IVF disposables: how do manufacturers test?    
8410 (0) Our study confirms the high degree of heterogeneity of the embryotoxicity tests performed by manufacturers when validating their IVF disposable devices. Currently, no regulations exist on this issue. Professionals should call for and request standardization and a future higher degree of transparency as regards embryotoxicity testing from supplying companies: moreover, companies should be urged to provide the users clear and precise information ab
View embryotoxicity testing/human sperm survival assay/mouse embryo assay,/IVF disposable/sensitivity/    

Prevalence of a Good Perinatal Outcome With Cryopreserved Compared With Fresh Donor Oocytes    
8409 (0) CONCLUSION: This retrospective national study demonstrated that the use of cryopreserved compared with fresh donor oocytes in IVF cycles is associated with marginally lower odds of a good perinatal outcome.
View Donor Oocytes/Cryopreserved oocytes/    

NAD+ Repletion Rescues Female Fertility during Reproductive Aging    
8408 (0) Treatment with the NAD+ metabolic precursor nicotinamide mononucleotide (NMN) rejuvenates oocyte quality in aged animals, leading to restoration in fertility, and this can be recapitulated by transgenic overexpression of the NAD+-dependent deacylase SIRT2, though deletion of this enzyme does not impair oocyte quality.
View nad+/sirt2/aging/mice/culture medium/nad+/ovarian aging/    

Scientists reverse reproductive clock in mice    
8407 (0) Researchers have lifted fertility rates in older female mice with small doses of a metabolic compound that reverses the aging process in eggs, offering hope for some women struggling to conceive.

Time-lapse imaging of cytoplasmic strings at the blastocyst stage suggests their association with spontaneous blastocoel collapse    
8406 (0) Conclusion: Time-lapse analysis of cytoplasmic strings at the blastocyst stage revealed that this morphological feature was not a negative predictor as previously reported. Although physiologically normal, at least some of the cytoplasmic strings are an artefact, possibly associated with blastocoelic collapses.
View blastocoel collapse/blastocyst morphology/cytoplasmic strings/morphokinetics/time-lapse/    

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