Fine-tuning blastocyst selection based on morphology: a multicentre analysis of 2461 single blastocyst transfers 
Conclusion: This large study analyses for the first time the independent role of blastocyst morphology in predicting live birth while controlling for female age and PdHCG. Its findings suggest that DevSt and then trophectoderm grade are stronger predictors of live birth over ICM grade when selecting a single blastocyst for transfer.
Title: Continuous Flow of Pre-Mixed Gas is not Required to Maintain Culture Medium pH in a Benchtop Incubator Presenter: Dr. David Mortimer 
BCSI is excited to invite you to join Dr. David Mortimer for a complimentary encore webinar presentation of his 2019 ESHRE oral abstract entitled, “Continuous Flow of Pre-Mixed Gas is not Required to Maintain Culture Medium pH in a Benchtop Incubator.” The initial presentation is also followed by a live discussion with webinar participants.
Cell-free nucleic acids and melatonin levels in human follicular fluid predict embryo quality in patients undergoing in-vitro fertilization treatment 
Conclusively, this study indicates that Intra-follicular cfDNA and melatonin concentration possibly a new supplemental tool that supports to establish an advanced non-invasive early prognostic test for the patients undergoing IVF/ICSI procedure.
Computer‐::aided sperm analysis, the new key player in routine sperm assessment 
Both manual and automated methods gave similar results for sperm concentration (n = 150), motility (n = 30), vitality (n = 90) and morphology (n = 90). Repeatability always showed a decrease in the CV with automated analysis: for example in normal range of sperm values, CV for manual and CASA analyses were, respectively, 9.0% versus 4.4% for sperm concentration, 5.2% versus 4.1% for motility, 7.3% versus 4.2% for vitality and 11.4% versus 4.1% fo
Modified MicroSecure Vitrification: A Safe, Simple and Highly Effective Cryopreservation Procedure for Human Blastocysts 
MicroSecure Vitrification was developed as a non-commercial, aseptic closed vitrification device system that is compliant with FDA good manufacturing and tissue-handling practices. Due to the withdrawal of hydrophobic plugged embryo straws from the industry, the vitrification procedure was modified to include an inner seal before the standard internal cotton plug.
The fight for access to a little girl that went all the way to the High Court 
The saga ended in a High Court decision that could shake up Australia's family law system — that a sperm donor had parental rights. At the centre of the legal posturing, which saw a friendship disintegrate and cost over $1 million, was a simple question: Could a sperm donor, in the right circumstances, actually be a legal father!
KIDScore™ - decision support tools for enhanced embryo [PDF] 
KIDScore D3 provides a morphokinetic score from 1-5 to your annotated embryos. The model gives you a score for each embryo from 1-6, reflecting the statistical chance of implantation based on development information from the five day culture period.
Performance of Day 5 KIDScore™ morphokinetic prediction models of implantation and live birth after single blastocyst transfer 
KIDScore™ Day 5 predictive models are significantly associated with implantation rates after day 5 single blastocyst transfer. However, their predictive performance remains perfectible. The use of these predictive models holds promises as decision-making tools to help the embryologist select the best embryo, ultimately facilitating the implementation of SET policy. However, embryologists’ expertise remains absolutely necessary to make the final d
IVF /Blastocyst/ Time-lapse/ Prediction model /Implantation / KIDScore/
Does a microfluidic chip for sperm sorting have a positive add‐::on effect on laboratory and clinical outcomes of intracytoplasmic sperm injectio 
No statistically significant differences were found between groups in terms of all outcomes analysed in laboratory and clinical terms (p > .05 for all). The results of this study suggest that sorting spermatozoa through Fertile chip does not improve laboratory outcomes significantly and does not seem to have a positive contribution to clinical outcomes.
Births from embryos with highly elevated levels of mitochondrial DNA 
Conclusions: Measurement of mtDNA copy number might not provide any advantage in embryo prioritization and could lead to a deselection of blastocysts that would result in healthy pregnancies and births. Furthermore, the quantification of mitochondrial functional output in a model of cellular stress might suggest that mitochondria are not clear targets for biomarker identification as it relates to blastocyst viability. Any suggested link between m
Subsidizing PGD: The Moral Case for Funding Genetic Selection 
We examine the objections to our proposal, specifically concerns regarding designer babies and the harm of disabled individuals, and show why these are substantially outweighed by arguments for subsidizing PGD. We argue that an acceptance of PGD is aligned with present attitudes towards procreative decision making and IVF use, and that it should therefore receive government funding.
Intracytoplasmic morphologically selected sperm injection, but for whom? 
Results were analysed to evaluate the effects of the IMSI procedure and to find the most suitable group of patients who may benefit from the procedure. IMSI caused a significant increase in the fertilization and top quality embryo rates in the male infertility group and a significant increase in fertilization and pregnancy rates in the repeated implantation failure group, whereas no effect was observed in the non-selected group with patients of v
Advanced sperm selection techniques for assisted reproduction 
The evidence suggests that sperm selected by hyaluronic acid binding may have little or no effect on live birth or clinical pregnancy but may reduce miscarriage. We are uncertain of the effect of Zeta sperm selection on live birth, clinical pregnancy, and miscarriage due principally to the very low quality of the evidence for this intervention. We are uncertain of the effect of the other selection techniques on live birth, miscarriage, or pregnan
Blastocyst biopsy and vitrification are required to efficiently conduct preimplantation genetic testing. An approach entailing the sequential opening of the zona pellucida and retrieval of 7-8 trophectoderm cells in day 5-7 post-insemination limits both the number of manipulations required and the exposure of the embryo to sub-optimal environmental conditions.
The effect of repeated controlled ovarian stimulation cycles on the gamete and embryo development 
Repeated COS does not seem to have any adverse effect on ovarian response to higher dose of artificial gonadotropin, as quality of oocytes collected and their embryological developmental potential were not affected by the number of successive stimulation cycles. The effect of multiple COS on the health of the oocyte donor needs to be assessed for future purpose.
Worldwide decline of IVF birth rates and its probable causes 
Over the past decade and a half, IVF, therefore, has increasingly disappointed outcome expectations. Remarkably, neither the profession nor the public have paid attention to this development which, therefore, also has gone unexplained. It now urgently calls for evidence-based explanations.
Environmental Exposure of Sperm Sex-Chromosomes: A Gender Selection Technique 
The results indicated successful enrichment of Xchromosome-bearing spermatozoa upon incubation in acidic media, increased temperatures, and elevated H2O2. This study demonstrated the potential role for exploring the physiological differences between X-and Y-chromosome-bearing spermatozoa in the development of preconceptual gender selection.
Activation of Toll-like receptor 7/8 encoded by the X chromosome alters sperm motility and provides a novel simple technology for sexing sperm 
Ligand activation of TLR7/8 selectively suppressed the mobility of the X chromosome–bearing sperm (X-sperm) but not the Y-sperm without altering sperm viability or acrosome formation. The difference in sperm motility allowed for the separation of Y-sperm from X-sperm. Following in vitro fertilization using the ligand-selected high-mobility sperm, 90% of the embryos were XY male. Likewise, 83% of the pups obtained following embryo transfer were XY