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ID Publications  
Cell volume regulation in oocytes and early embryos: connecting physiology to successful culture media [2021]
8951 This is an Open Access publication Early preimplantation embryos are particularly sensitive to increased osmolarity, and require the importation of glycine to regulate their cell volumes using a mechanism unique to early embryos. Cell volume regulation first appears when ovulation is triggered, oocyte zona pellucida adhesion is released, and glycine transport is activated.
OPEN academic.oup.com/humupd/article/16/2/166/738907
KW Osmolarity/

 
Sequential cleavage and blastocyst embryo transfer and IVF outcomes: a systematic review [2021]
8950 This is an Open Access publication The current systematic review demonstrates that sequential cleavage and blastocyst embryo transfer improve the clinical pregnancy rate over conventional cleavage embryo transfer. For women with adequate embryos, sequential transfer could be attempted following careful consideration.
OPEN rbej.biomedcentral.com/articles/10.1186/s12958-021-00824-y
KW sequential embryo transfer/blastocyst/cleavage transfer/the study/

 
Podocalyxin is a key negative regulator of human endometrial epithelial receptivity for embryo implantation [2021]
8949 This is an subscription based  publication Podocalyxin (PCX), a transmembrane protein, was identified as a key negative regulator of endometrial epithelial receptivity: specific downregulation of PCX in the luminal epithelium in the mid-secretory phase, likely mediated by progesterone, may act as a critical step in converting endometrial surface from a non-receptive to an implantation-permitting state.
OPEN academic.oup.com/humrep/article-abstract/36/5/1353/6209121
KW embryo implantation/endometrium/epithelial cells/podocalyxin/implantation/uterine receptivity/

 
Podocalyxin is a key negative regulator of human endometrial epithelial receptivity for embryo implantation [2021]
8948 This is an subscription based  publication Podocalyxin (PCX), a transmembrane protein, was identified as a key negative regulator of endometrial epithelial receptivity: specific downregulation of PCX in the luminal epithelium in the mid-secretory phase, likely mediated by progesterone, may act as a critical step in converting endometrial surface from a non-receptive to an implantation-permitting state.
OPEN academic.oup.com/humrep/article-abstract/36/5/1353/6209121
KW embryo implantation/endometrium/epithelial cells/podocalyxin/implantation/uterine receptivity/

 
Lifestyle intervention prior to IVF does not improve embryo utilization rate and cumulative live birth rate in women with obesity: a nested cohort stu [2021]
8947 This is an Open Access publication SUMMARY ANSWER. A 6-month lifestyle intervention preceding IVF improved neither EUR nor CLBR in women with obesity in the first IVF treatment cycle where at least one oocyte was retrieved.
OPEN academic.oup.com/hropen/advance-article/doi/10.1093/hropen/hoab032/6345351
KW Lifestyle/Intervention/obese/CPR/

 
Predictive value of cytoplasmic granulation patterns during in vitro fertilization in metaphase II oocytes: part II, donor oocyte cycles [2021]
8946 This is an Open Access publication Predictive values of oocyte granulation patterns for fertilization, pregnancy, and live birth in IVF cycles are even more pronounced in young donors than results in older poor-prognosis patients, further supporting integration of oocyte granulation patterns into embryo selection.
OPEN www.fertstert.org/article/S0015-0282(21)00526-4/fulltext
KW Oocyte/

 
WHO laboratory manual for the examination and processing of human semen Sixth Edition [2021]
8945 This is an Open Access publication This sixth edition of the manual will be an essential source of the latest evidencebased information for the laboratory procedures needed for fertility care. This edition has new and expanded sections on semen sample preparation, determining markers for infection, computer-aided sperm analysis, and basic extended and advanced categories.
OPEN www.ivfcpd.com/PDF/WHO_6th_edition.pdf
KW WHO/Semen analysis/guidelines

 
Wilfried Feichtinger (1950–2021): an Austrian IVF pioneer [2021]
8944 This is an Open Access publication Early morning on 3 June, my father, Wilfried Feichtinger, an early-day IVF pioneer, passed away at the age of 70 after a long and hard fight against cancer.
OPEN https:www.rbmojournal.com/article/S1472-6483(21)00297-2/fulltext
KW Obituary/

 
Comparison of aneuploidy rates between conventional in vitro fertilization and intracytoplasmic sperm injection in in vitro fertilization–intracytopla [2021]
8943 This is an Open Access publication Blastocysts created with conventional IVF and ICSI using sibling oocytes had similar rates of aneuploidy and mosaicism as examined using 24-chromosome screening. It is unlikely that conventional IVF caused significant contamination during PGT-A
OPEN www.fertstertreports.org/article/S2666-3341(20)30045-3/fulltext
KW Aneuploidy/mosaicism/PGT-A/ICSI/

 
SART Fertility Experts Podcasts [2021]
8942 This is an Open Access publication "An educational project of the Society for Assisted Reproductive Technology, this series is designed to provide up to date information about a variety of topics related to fertility testing and treatment such as IVF.
OPEN startwithsart.libsyn.com/
KW Podcast/

 
SART Fertility Experts - Behind the Scenes in the IVF Lab [2021]
8941 This is an Open Access publication "Dr. Sangita Jindal, Associate Professor at Albert Einstein College of Medicine and Laboratory Director at Montefiore’s Institute for Reproductive Medicine and Health helps patients understand the importance of the IVF lab when choosing an IVF program. She also explains the rigorous training of embryologists, laboratory safety, as well as identification and cryo-storage of eggs, sperm and embryos in the lab. From eggs to embryos, the lab’s esse
OPEN startwithsart.libsyn.com/sart-fertility-experts-behind-the-scenes-in-the-ivf-lab
KW Podcast/IVF laboratory/

 
Cumulative live birth rate after IVF: trend over time and the impact of blastocyst culture and vitrification [2021]
8940 This is an Open Access publication During an 11-year period, 2007–2017, CLBR per oocyte aspiration increased significantly, from 27.0% to 36.3%, in parallel with an increase in blastocyst transfer and cryopreservation by vitrification
OPEN academic.oup.com/hropen/article/2021/3/hoab021/6311058
KW

 
Human embryos cultured in lab for record time a 'major step forward' that opens ethical debate [2021]
8939 This is an Open Access publication For the first time, scientists have kept human embryos alive in the laboratory for six days beyond the point at which it would normally implant into the uterus.
OPEN www.abc.net.au/news/science/2016-05-05/human-embryos-grown-in-the-lab-up-to-14-days/738400
KW Stem cells/Embryoids/

 
Why scientists want longstanding '14-day rule' for human embryo research changed [2021]
8938 This is an Open Access publication Scientists want the rules governing the use of human embryos to change, saying they are stopping potentially life-changing research.
OPEN www.abc.net.au/news/science/2021-06-27/human-embryo-14-day-rule-legislation-stem-cell-rese
KW Stem cells/Embryoids/

 
Risk of breast cancer in women treated with ovarian stimulation drugs for infertility: a systematic review and meta-analysis [2021]
8937 This is an subscription based  publication The current study found that the use of clomiphene citrate and gonadotropins in infertile women was not associated with an increased risk of breast cancer.
OPEN www.fertstert.org/article/S0015-0282(21)00077-7/fulltext
KW Breast cancer/clomiphene citrate/gonadotropins/

 
Outcomes comparison of IVF/ICSI among different trigger methods for final oocyte maturation: A systematic review and meta-analysis [2021]
8936 This is an Open Access publication However, there was no significant difference between the two groups in terms of pregnancy rate. The FSH co-trigger resulted in significantly higher rates of 2PN oocytes retrieved than the hCG trigger (WMD 0.077, 95% CI 0.028-0.126).
OPEN faseb.onlinelibrary.wiley.com/doi/10.1096/fj.202100406R
KW dual triggers/Ovualtion induction/

 
Ovarian Hyperstimulation Syndrome Is Associated with a High Secondary Sex Ratio in Fresh IVF Cycles with Cleavage-Stage Embryo Transfer: Results for a [2021]
8935 This is an subscription based  publication The SSR was significantly increased in patients with moderate OHSS (1.336) compared to non-OHSS patients (1.002) (p=0.048). Subgroup analyses showed that increases in the SSR in patients with moderate OHSS were observed in the IVF group (1.323 vs 1.052: p=0.043), but not in the ICSI groups (1.021 vs 0.866: p=0.732).
OPEN link.springer.com/article/10.1007%2Fs43032-021-00637-9
KW ssr/secondary sex ration/ohss/ivfcpd comment/

 
The Effect of Luteinising Hormone Suppression in In Vitro Fertilisation Antagonist Cycles [2021]
8934 This is an subscription based  publication We found associations between clinical characteristics and risk of profound LH suppression in women undergoing GnRH antagonist IVF cycles, but no significant differences in IVF and pregnancy outcomes between women with and without significant LH suppression.
OPEN link.springer.com/article/10.1007%2Fs43032-021-00608-0
KW LH/LUSuppression/Luteinizing Hormone/

 
GnRH agonist and hCG (dual trigger) versus hCG trigger for follicular maturation: a systematic review and meta-analysis of randomized trials [2021]
8933 This is an Open Access publication Conclusion: Dual trigger treatment with GnRH agonist and HCG is associated with an increased live birth rate compared with conventional hCG trigger.
OPEN rbej.biomedcentral.com/articles/10.1186/s12958-021-00766-5
KW Stimulation/Ovulation induction/OHSS/Dual Trigger/

 
Low dose hCG supplementation in a Gn-RH-agonist trigger protocol is associated with worse pregnancy outcomes: a retrospective cohort study [2021]
8932 This is an Open Access publication The dual trigger group had a better prognosis based on age and AMH levels and had better stimulation outcomes, but significantly worse pregnancy outcomes, suggesting the low dose hCG (1000u) in the dual trigger may not have provided adequate luteal support, compared to an hCG-only trigger (10,000u hCG/250-500 μ:g Ovidrel).
OPEN fertilityresearchandpractice.biomedcentral.com/articles/10.1186/s40738-021-00104-8
KW Stimulation/Ovulation induction/OHSS/

 
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