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List of Recent Publications. There are 20 links to this search
ID Publications  
       
Noninvasive preimplantation genetic testing for aneuploidies (niPGT-A) and the principle of primum non nocere [1899]
8708 Perhaps with the intention of obtaining larger amounts of free-DNA, some groups are routinely postponing and establishing free-DNA collection in culture medium for Noninvasive preimplantation genetic testing for aneuploidies (niPGT-A) to day 6 for all blastocysts.
OPEN
KW Noninvasive preimplantation genetic test

 
Embryo Ranking Intelligent Classification Algorithm (ERICA): artificial intelligence clinical assistant predicting embryo ploidy and implantation [2020]
8707 This is an Open Access publication We have trained ERICA to rank embryos based on ploidy and implantation potential using single static embryo image. This tool represents a potentially significant advantage to assist embryologists to choose the best embryo, saving time spent annotating and does not require time lapse or invasive biopsy
OPEN www.rbmojournal.com/article/S1472-6483(20)30373-4/fulltext
KW ART utilization /Artificial intelligence/ IVF drop-outs /Machine learning /Patient empathy/ Prognostication/ ERICA/ Noninvasive embryo assessment/

 
Failure mode and effects analysis of witnessing protocols for ensuring traceability during PGD/PGS cycles [2020]
8706 This is an Open Access publication Specific corrective measures were then introduced and implemented, and a second evaluation performed six months later. The meticulous and careful application of such measures allowed the risks to be decreased along the whole protocol, by reducing their estimated occurrence and/or increasing detection possibilities.
OPEN www.rbmojournal.com/article/S1472-6483(20)30464-8/fulltext
KW misdiagnosis/mismatch/preimplantation genetic screening (PGS)/traceability./

 
Preimplantation genetic testing as a component of root cause analysis of errors and reassignment of embryos in IVF [2020]
8705 This is an Open Access publication The risks of embryo/gamete mix-up are a threat to the integrity of the IVF process, with significant implications for affected families. The use of preimplantation genetic testing through single-nucleotide polymorphism array or next-generation sequencing technology can help to identify, characterize and ultimately help, in some cases, to find the root cause, and to mitigate the extent of these errors for a given patient or laboratory.
OPEN www.rbmojournal.com/article/S1472-6483(20)30464-8/fulltext
KW Embryo biopsy/IVF errors/Paternity testing/

 
Blastocyst contractions are strongly related with aneuploidy, lower implantation rates, and slow-cleaving embryos: a time lapse study [2020]
8704 This is an Open Access publication Two of the traits for which the embryos included in this study were compared were statistically different. Embryos in the CT group had lower implantation rates, took longer to reach the blastocyst stage, and had a higher chance of being aneuploid, regardless of maternal age. Therefore, embryo contraction might be a useful parameter in the selection of embryos for transfer.
OPEN www.ncbi.nlm.nih.gov/pmc/articles/PMC6993166/
KW blastocyst contraction/

 
Blastocyst collapse as an embryo marker of low implantation potential: a time-lapse multicentre study [2020]
8703 This is an subscription based  publication This study suggests that human blastocysts that collapse spontaneously during development are less likely to implant and generate a pregnancy compared with embryos that do not. Although this is a retrospective study, the results demonstrated the utility of collapse episodes as new marker of embryo selection following eSET at blastocyst stage.
OPEN doi.org/10.1017/S0967199419000819
KW spontaneous blastocyst collapse/ time lapse/embryo quality/

 
Spontaneous blastocyst collapse as an embryo marker of low pregnancy outcome: A Time-Lapse study [2020]
8702 This is an subscription based  publication This study demonstrated that human blastocysts which collapse spontaneously during in vitro development are less likely to implant and generate a pregnancy compared with embryos which do not. Although this is a retrospective study, the results establish the utility of collapse episodes as new marker of embryo selection following eSET at blastocyst stage.
OPEN pubmed.ncbi.nlm.nih.gov/31397550/
KW spontaneous blastocyst collapse/ time lapse/embryo quality/

 
Extended in vitro culture of human embryos demonstrates the complex nature of diagnosing chromosomal mosaicism from a single trophectoderm biopsy [2020]
8701 This is an subscription based  publication Our findings echo current prenatal testing data and support the high clinical predictive value of PGT-A for diagnosing uniform numerical aneuploidies, as well as euploid chromosomal constitutions. However, distinguishing technical bias from biological variability will remain a challenge, inherently limiting the accuracy of a single TE biopsy for diagnosing mosaicism.
OPEN academic.oup.com/humrep/article-abstract/34/4/758/5369984
KW Aneupolidy/ extended Culture/

 
Developmental potential of aneuploid human embryos cultured beyond implantation [2020]
8700 This is an Open Access publication We show that while trisomy 15 and trisomy 21 embryos develop similarly to euploid embryos, monosomy 21 embryos exhibit high rates of developmental arrest, and trisomy 16 embryos display a hypo-proliferation of the trophoblast, the tissue that forms the placenta.
OPEN www.nature.com/articles/s41467-020-17764-7
KW aneupolidy/in vitro extended culture/

 
Clinical Outcomes of Single Mosaic Embryo Transfer: High-Level or Low-Level Mosaic Embryo, Does it Matter? [2020]
8699 This is an Open Access publication Comparable live birth rate (LBR) but higher miscarriage rate (MR) was found in the high-level group. (LBR: low vs. high: 44.5% vs. 36%, p=0.45, MR: low vs. high: 5.1% vs. 30.7%, p=0.012). Analyses of TE and ICM from the remaining mosaic blastocysts show a poor concordance.
OPEN www.ncbi.nlm.nih.gov/pmc/articles/PMC7356018/
KW aneuploidy/mosaic/PGT-A/

 
DNA fragmentation of sperm: a radical examination of the contribution of oxidative stress and age in 16 945 semen samples [2020]
8698 This is an subscription based  publication DNA and/or oxidative damage in sperm may be just as important to understand as the chromosomal aberrations that are carried in the oocyte. Further studies are needed to evaluate the effect of advancing paternal age on the male genome and, ultimately, on the health of the offspring.
OPEN academic.oup.com/humrep/article-abstract/35/10/2188/5903064
KW sperm dna damage/sperm dna fragmentation/oxidative stress/sperm dna fragmentation and paternal age/

 
Minimizing mosaicism: assessing the impact of fertilization method on rate of mosaicism after next-generation sequencing (NGS) preimplantation genetic [2020]
8697 This is an Open Access publication IVF and ICSI NGS PGT-A have similar rates of euploid, aneuploid, and no result embryos, though IVF may result in higher rates of mosaicism and demonstrates differences in proportions of mosaic and aneuploid subtypes compared to ICSI. ICSI may be preferable to conventional insemination to minimize the rate of mosaic results in NGS PGT-A cycles
OPEN link.springer.com/article/10.1007/s10815-018-1347-6
KW mosaicism/chromosomal mosaicism and pgt-a/

 
One hundred mosaic embryos transferred prospectively in a single clinic: exploring when and why they result in healthy pregnancies [2020]
8696 This is an Open Access publication After euploid embryos, mosaic embryos can be considered for transfer, prioritizing those of the single segmental mosaic type. If a patient has mosaic embryos available that were generated at different ages, preference should be given to those made at younger ages.
OPEN www.fertstert.org/article/S0015-0282(18)32141-1/fulltext
KW mosaic embryo transfer (MET)/PGT-A/

 
The birth of a baby with mosaicism resulting from a known mosaic embryo transfer: a case report [2020]
8695 This is an Open Access publication This is the first reported case of true fetal mosaicism resulting in a live birth following the transfer of a known mosaic embryo. Worldwide, prenatal diagnosis has shown the depletion of mosaicism in embryos transferred after they have been reported as mosaics. Our case demonstrates the need for close prenatal monitoring and diagnosis by early amniocentesis, preferably at >14 weeks gestation.
OPEN academic.oup.com/humrep/article/35/3/727/5799250
KW mosaicism/ PGT-A/

 
Preimplantation genetic testing for aneuploidy: are we examining the correct outcomes? [2020]
8694 This is an subscription based  publication This article describes the concern that a focus on results from the first embryo transfer compared to cumulative outcomes falsely construes PGT-A as having superior outcomes, whilst its true benefit is not confirmed, and it cannot actually improve the true pregnancy outcome of an embryo pool.
OPEN academic.oup.com/humrep/advance-article-abstract/doi/10.1093/humrep/deaa224/5910339
KW pgt-a/ivf/outcomes, embryo/rcts/cumulative outcomes/pgt-a and cumulative pregnancy rate/

 
Assessment of uterine activity during IVF by quantitative ultrasound imaging: a pilot study [2020]
8693 This is an subscription based  publication It is an essential step to understanding the previously suggested effect of contractions on IVF failure. Uterine activity after embryo transfer characterized by high frequency and low amplitude may favour embryo implantation. Research with larger patient cohorts is needed to build on current evidence and knowledge of uterine contractions during IVF.
OPEN www.rbmojournal.com/article/S1472-6483(20)30439-9/fulltext
KW embryo implantation ivf/ ongoing pregnancy /quantitative ultrasound imaging /uterine contractility/uterine activity/

 
The combined effect of obesity and aging on human sperm DNA methylation signatures: inclusion of BMI in the paternal germ line age prediction model [2020]
8692 This is an Open Access publication However, it is important to note that within each age category, high BMI individuals were predicted to be older on average than their actual age (about 1.4 years), which was not observed in the normal BMI group.
OPEN www.nature.com/articles/s41598-020-71979-8
KW Paternal Age.DNA Methylation/BMI/

 
Cumulative live birth rates following blastocyst- versus cleavage-stage embryo transfer in the first complete cycle of IVF: a population-based retrosp [2020]
8691 This is an subscription based  publication Our findings show that blastocyst-stage embryo transfer may offer an improved chance of live birth in both the first fresh and the first complete cycle of IVF/ICSI compared to cleavage-stage transfer, even in couples with typically poorer prognoses..However, after accounting for the imbalance between exposures, blastocyst transfer did not significantly influence the odds of live birth over the first complete cycle.
OPEN academic.oup.com/humrep/advance-article-abstract/doi/10.1093/humrep/deaa186/5908895
KW cumulative live birth rate/CLB/blastocyst/

 
Degenerated oocyte in the cohort adversely affects IVF outcome [2020]
8690 This is an Open Access publication Fertilization rate, pregnancy and clinical pregnancy rates were comparable between the two groups, however, the morphokinetics and developmental scores of the embryos were significantly worse in the DEG group.
OPEN ovarianresearch.biomedcentral.com/articles/10.1186/s13048-020-00708-6
KW Aspiration needle/Degenerated oocyte/Embryo morphokinetics/Ovum pick-up/OPU/

 
The reproducibility of trophectoderm biopsies in euploid, aneuploid, and mosaic embryos using independently verified next-generation sequencing (NGS): [2020]
8689 This is an Open Access publication TE biopsies predict euploidy or aneuploidy in the ICM with a high degree of accuracy. PGT-A with NGS of TE biopsies is shown to be highly reliable, with clinically relevant concordance rates for aneuploidy and euploidy over 95%.
OPEN link.springer.com/article/10.1007/s10815-020-01720-x
KW Inner cell mass/Mosaic/Next-generation sequencing/Trophectoderm biopsy/ICM.NGS.PGT-A/

 
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