Cell volume regulation in oocytes and early embryos: connecting physiology to successful culture media [2021]
8951
Early preimplantation embryos are particularly sensitive to increased osmolarity, and require the importation of glycine to regulate their cell volumes using a mechanism unique to early embryos. Cell volume regulation first appears when ovulation is triggered, oocyte zona pellucida adhesion is released, and glycine transport is activated.
Sequential cleavage and blastocyst embryo transfer and IVF outcomes: a systematic review [2021]
8950
The current systematic review demonstrates that sequential cleavage and blastocyst embryo transfer improve the clinical pregnancy rate over conventional cleavage embryo transfer. For women with adequate embryos, sequential transfer could be attempted following careful consideration.
Podocalyxin is a key negative regulator of human endometrial epithelial receptivity for embryo implantation [2021]
8949
Podocalyxin (PCX), a transmembrane protein, was identified as a key negative regulator of endometrial epithelial receptivity: specific downregulation of PCX in the luminal epithelium in the mid-secretory phase, likely mediated by progesterone, may act as a critical step in converting endometrial surface from a non-receptive to an implantation-permitting state.
Podocalyxin is a key negative regulator of human endometrial epithelial receptivity for embryo implantation [2021]
8948
Podocalyxin (PCX), a transmembrane protein, was identified as a key negative regulator of endometrial epithelial receptivity: specific downregulation of PCX in the luminal epithelium in the mid-secretory phase, likely mediated by progesterone, may act as a critical step in converting endometrial surface from a non-receptive to an implantation-permitting state.
Lifestyle intervention prior to IVF does not improve embryo utilization rate and cumulative live birth rate in women with obesity: a nested cohort stu [2021]
8947
SUMMARY ANSWER. A 6-month lifestyle intervention preceding IVF improved neither EUR nor CLBR in women with obesity in the first IVF treatment cycle where at least one oocyte was retrieved.
Predictive value of cytoplasmic granulation patterns during in vitro fertilization in metaphase II oocytes: part II, donor oocyte cycles [2021]
8946
Predictive values of oocyte granulation patterns for fertilization, pregnancy, and live birth in IVF cycles are even more pronounced in young donors than results in older poor-prognosis patients, further supporting integration of oocyte granulation patterns into embryo selection.
WHO laboratory manual for the examination and processing of
human semen Sixth Edition [2021]
8945
This sixth edition of the manual will be an essential source of the latest evidencebased information for the laboratory procedures needed for fertility care. This
edition has new and expanded sections on semen sample preparation, determining
markers for infection, computer-aided sperm analysis, and basic extended and
advanced categories.
Wilfried Feichtinger (1950–2021): an Austrian IVF pioneer [2021]
8944
Early morning on 3 June, my father, Wilfried Feichtinger, an early-day IVF pioneer, passed away at the age of 70 after a long and hard fight against cancer.
Comparison of aneuploidy rates between conventional in vitro fertilization and intracytoplasmic sperm injection in in vitro fertilization–intracytopla [2021]
8943
Blastocysts created with conventional IVF and ICSI using sibling oocytes had similar rates of aneuploidy and mosaicism as examined using 24-chromosome screening. It is unlikely that conventional IVF caused significant contamination during PGT-A
"An educational project of the Society for Assisted Reproductive Technology, this series is designed to provide up to date information about a variety of topics related to fertility testing and treatment such as IVF.
SART Fertility Experts - Behind the Scenes in the IVF Lab [2021]
8941
"Dr. Sangita Jindal, Associate Professor at Albert Einstein College of Medicine and Laboratory Director at Montefiore’s Institute for Reproductive Medicine and Health helps patients understand the importance of the IVF lab when choosing an IVF program. She also explains the rigorous training of embryologists, laboratory safety, as well as identification and cryo-storage of eggs, sperm and embryos in the lab. From eggs to embryos, the lab’s esse
Cumulative live birth rate after IVF: trend over time and the impact of blastocyst culture and vitrification [2021]
8940
During an 11-year period, 2007–2017, CLBR per oocyte aspiration increased significantly, from 27.0% to 36.3%, in parallel with an increase in blastocyst transfer and cryopreservation by vitrification
Human embryos cultured in lab for record time a 'major step forward' that opens ethical debate [2021]
8939
For the first time, scientists have kept human embryos alive in the laboratory for six days beyond the point at which it would normally implant into the uterus.
Risk of breast cancer in women treated with ovarian stimulation drugs for infertility: a systematic review and meta-analysis [2021]
8937
The current study found that the use of clomiphene citrate and gonadotropins in infertile women was not associated with an increased risk of breast cancer.
Outcomes comparison of IVF/ICSI among different trigger methods for final oocyte maturation: A systematic review and meta-analysis [2021]
8936
However, there was no significant difference between the two groups in terms of pregnancy rate. The FSH co-trigger resulted in significantly higher rates of 2PN oocytes retrieved than the hCG trigger (WMD 0.077, 95% CI 0.028-0.126).
Ovarian Hyperstimulation Syndrome Is Associated with a High Secondary Sex Ratio in Fresh IVF Cycles with Cleavage-Stage Embryo Transfer: Results for a [2021]
8935
The SSR was significantly increased in patients with moderate OHSS (1.336) compared to non-OHSS patients (1.002) (p=0.048). Subgroup analyses showed that increases in the SSR in patients with moderate OHSS were observed in the IVF group (1.323 vs 1.052: p=0.043), but not in the ICSI groups (1.021 vs 0.866: p=0.732).
The Effect of Luteinising Hormone Suppression in In Vitro Fertilisation Antagonist Cycles [2021]
8934
We found associations between clinical characteristics and risk of profound LH suppression in women undergoing GnRH antagonist IVF cycles, but no significant differences in IVF and pregnancy outcomes between women with and without significant LH suppression.
