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FIVFCPD - Reference Library.
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IVF eLearning Reference LIBRARY

IVF Training has developed a list of references, some of which are used as a reference source throughout IVF e-Learning modules. You are welcome to use this reference or the PDF library as an alternative tool for online learning. Access is unrestricted and new links are welcome especially from manufacturers and clinics.

Note: this section requires significant further maintenance associated with its move to

CPD Sections All References Clinical Andrology ART Cycles Embryology PsychoSocial Laboratory General Business
IVF e-Learning Reference List -
ID Name    
Handayani N, Aubry D, Boediono A, Wiweko B, Sirait B, Sini I, Polim AA, Dwiranti A, Bowolaksono A. The origin and possible mechanism of embryonic cell-free DNA release in spent embryo culture media: a review. J Assist Reprod Genet. 2023 Jun,40(6):1231-1242. doi: 10.1007/s10815-023-02813-z.    
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Bickendorf K, Qi F, Peirce K, Natalwala J, Chapple V, Liu Y. Spontaneous collapse as a prognostic marker for human blastocysts: a systematic review and meta-analysis. Hum Reprod. 2023 Aug 15:dead166. doi: 10.1093/humrep/dead166    
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Cabry R, Merviel P, Madkour A, Lefranc E, Scheffler F, Desailloud R, Bach V, Benkhalifa M. The impact of endocrine disruptor chemicals on oocyte/embryo and clinical outcomes in IVF. Endocr Connect. 2020 Jun,9(6):R134-R142. doi: 10.1530/EC-20-0135. PMID: 32380469, PMCID: PMC7354731.    
4697/0/10.1530/EC-20-0135. PMID: 32380469, PMCID: PMC7354   View
Jřrgensen N, Lamb DJ, Levine H, Pastuszak AW, Sigalos JT, Swan SH, Eisenberg ML. Are worldwide sperm counts declining? Fertil Steril. 2021 Dec,116(6):1457-1463. doi: 10.1016/j.fertnstert.2021.10.020. PMID: 34836581.    
4696/0/10.1016/j.fertnstert.2021.10.020. PMID: 34836581.   View
Levine H, Jřrgensen N, Martino-Andrade A, Mendiola J, Weksler-Derri D, Jolles M, Pinotti R, Swan SH. Temporal trends in sperm count: a systematic review and meta-regression analysis of samples collected globally in the 20th and 21st centuries. Hum Reprod Update. 2023 Mar 1,29(2):157-176. doi: 10.1093/humupd/dmac035. PMID: 36377604.    
4695/0/10.1093/humupd/dmac035. PMID: 36377604.   View
Morbeck DE, Baumann NA, Oglesbee D. Composition of single-step media used for human embryo culture. Fertil Steril. 2017 Apr,107(4):1055-1060.e1. doi: 10.1016/j.fertnstert.2017.01.007    
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FitzHarris G, Baltz JM. Regulation of intracellular pH during oocyte growth and maturation in mammals. Reproduction. 2009 Oct,138(4):619-27. doi: 10.1530/REP-09-0112    
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Wu J, Huang J, Dong J, Xiao X, Li M, Wang X. The thicker the endometrium, the better the neonatal outcomes? Hum Reprod Open. 2023 Jul 13,2023(3):hoad028. doi: 10.1093/hropen/hoad028    
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Mathyk B, Schwartz A, DeCherney A, Ata B. A critical appraisal of studies on endometrial thickness and embryo transfer outcome. Reprod Biomed Online. 2023 Jul 3,47(4):103259. doi: 10.1016/j.rbmo.2023.103259    
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Palomba S,and more: Italian Society of Human Reproduction (SIRU). Fertility specialists' views, behavior, and attitudes towards the use of endometrial scratching in Italy. BMC Womens Health. 2023 Jul 29,23(1):397. doi: 10.1186/s12905-023-02564-0    
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Joo K, Nemes A, Dudas B, Berkes-Bara E, Murber A, Urbancsek J, Fancsovits P. The importance of cytoplasmic strings during early human embryonic development. Front Cell Dev Biol. 2023 Jul 11,11:1177279. doi: 10.3389/fcell.2023.1177279    
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Wu J, Huang J, Dong J, Xiao X, Li M, Wang X. The thicker the endometrium, the better the neonatal outcomes? Hum Reprod Open. 2023 Jul 13,2023(3):hoad028. doi: 10.1093/hropen/hoad028. PMID: 37489142, PMCID: PMC10363027.    
4687/0/10.1093/hropen/hoad028   View
Cimadomo D, Capalbo A, Dovere L, Tacconi L, Soscia D, Giancani A, Scepi E, Maggiulli R, Vaiarelli A, Rienzi L, Ubaldi FM. Leave the past behind: women's reproductive history shows no association with blastocysts' euploidy and limited association with live birth rates after euploid embryo transfers. Hum Reprod. 2021 Mar 18,36(4):929-940. doi: 10.1093/humrep/deab014. PMID: 33608730.    
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Vitagliano A, Paffoni A, Viganň P. Does maternal age affect assisted reproduction technology success rates after euploid embryo transfer? A systematic review and meta-analysis. Fertil Steril. 2023 Mar 5:S0015-0282(23)00169-3. doi: 10.1016/j.fertnstert.2023.02.036    
4685/0/10.1016/j.fertnstert.2023.02.036   View
Kakourou G, Mamas T, Vrettou C, Traeger-Synodinos J. An Update on Non-invasive Approaches for Genetic Testing of the Preimplantation Embryo. Curr Genomics. 2022 Nov 18,23(5):337-352. doi: 10.2174/1389202923666220927111158. PMID: 36778192, PMCID: PMC9878856.    
4684/0/10.2174/1389202923666220927111158. PMID: 36778192,   View
Magli MC, Albanese C, Crippa A, Tabanelli C, Ferraretti AP, Gianaroli L. Deoxyribonucleic acid detection in blastocoelic fluid: a new predictor of embryo ploidy and viable pregnancy. Fertil Steril. 2019 Jan,111(1):77-85. doi: 10.1016/j.fertnstert.2018.09.016    
4683/0/10.1016/j.fertnstert.2018.09.016   View
L Gianaroli and others, Failure to detect DNA in blastocoel fluid is associated with a higher live birth rate in both PGT-A and conventional IVF/ICSI cycles, Human Reproduction, Volume 38, Issue 7, July 2023, Pages 1268–1276,    
4682/0/10.1093/humrep/dead088   View
Kermack AJ, Fesenko I, Christensen DR, Parry KL, Lowen P, Wellstead SJ, Harris SF, Calder PC, Macklon NS, Houghton FD. Incubator type affects human blastocyst formation and embryo metabolism: a randomized controlled trial. Hum Reprod. 2022 Nov 24,37(12):2757-2767. doi: 10.1093/humrep/deac233    
4681/0/10.1093/humrep/deac233   View
Wang S, Qi L, Liu Y, Shi H, Chen X, Wang N, Su Y. Suitable endometrial thickness on embryo transfer day may reduce ectopic pregnancy rate and improve clinical pregnancy rate. BMC Pregnancy Childbirth. 2023 Jul 15,23(1):517. doi: 10.1186/s12884-023-05837-6    
4680/0/10.1186/s12884-023-05837-6   View
Wang F, McCulloh DH, Chan K, Wiltshire A, McCaffrey C, Grifo JA, Keefe DL. The Landscape of Telomere Length and Telomerase in Human Embryos at Blastocyst Stage. Genes (Basel). 2023 May 30,14(6):1200. doi: 10.3390/genes14061200. PMID: 37372380, PMCID: PMC10298191.    
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Katherine Koniares, Claudio Benadiva, Lawrence Engmann,John Nulsen, Daniel Grow. Macroprolactinemia: a mini-review and update on clinical practice. FS Reports. 2023. doi:10.1016/j.xfre.2023.05.005    
4676/0/10.1016/j.xfre.2023.05.005   View
Munro MG, Balen AH, Cho S, Critchley HOD, Díaz I, Ferriani R, Henry L, Mocanu E, van der Spuy ZM, FIGO Committee on Menstrual Disorders and Related Health Impacts, and FIGO Committee on Reproductive Medicine, Endocrinology, and Infertility. The FIGO Ovulatory Disorders Classification System†. Hum Reprod. 2022 Sep 30,37(10):2446-2464. doi: 10.1093/humrep/deac180. PMID: 35984284, PMCID: PMC9527465.    
4675/0/10.1093/humrep/deac180   View
Du M, Zhang J, Wei Z, Li L, Liu X, Liu M, Wang X, Guan Y. Season and temperature do not affect cumulative live birth rate and time to live birth in in vitro fertilization. Front Endocrinol (Lausanne). 2023 Jun 21,14:1156299. doi: 10.3389/fendo.2023.1156299. PMID: 37424872, PMCID: PMC10325717.    
4674/0/10.3389/fendo.2023.1156299   View
Meng H, Huang S, Diao F, Gao C, Zhang J, Kong L, Gao Y, Jiang C, Qin L, Chen Y, Xu M, Gao L, Liang B, Hu Y. Rapid and non-invasive diagnostic techniques for embryonic developmental potential: a metabolomic analysis based on Raman spectroscopy to identify the pregnancy outcomes of IVF-ET. Front Cell Dev Biol. 2023 Jun 23,11:1164757. doi: 10.3389/fcell.2023.1164757. PMID: 37427383, PMCID: PMC1032662    
4673/0/10.3389/fcell.2023.1164757   View
Abdi M, Alizadeh F, Daneshi E, Abouzaripour M, Fathi F, Rahimi K. Ameliorative effect of Stevia rebaudiana Bertoni on sperm parameters, in vitro fertilization, and early embryo development in a streptozotocin-induced mouse model of diabetes. Zygote. 2023 Jul 7:1-8. doi: 10.1017/S0967199423000266    
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Domingo-Muelas A, et al. Human embryo live imaging reveals nuclear DNA shedding during blastocyst expansion and biopsy. Cell. 2023 Jun 28:S0092-8674(23)00643-8. doi: 10.1016/j.cell.2023.06.003    
4671/0/10.1016/j.cell.2023.06.003   View
Leathersich SJ, Roche CS, Walls M, Nathan E, Hart RJ. Season at the time of oocyte collection and frozen embryo transfer outcomes. Hum Reprod. 2023 Jul 5:dead137. doi: 10.1093/humrep/dead137    
4670/0/10.1093/humrep/dead137   View
Wiegel RE, Rubini E, Rousian M, Schoenmakers S, Laven JSE, Willemsen SP, Baart EB, Steegers-Theunissen RPM. Human oocyte area is associated with preimplantation embryo usage and early embryo development: the Rotterdam Periconception Cohort. J Assist Reprod Genet. 2023 Jun,40(6):1495-1506. doi: 10.1007/s10815-023-02803-1    
4669/0/10.1007/s10815-023-02803-1   View
Canosa S, Maggiulli R, Cimadomo D, Innocenti F, Fabozzi G, Gennarelli G, Revelli A, Bongioanni F, Vaiarelli A, Ubaldi FM, Rienzi L, Palmer GA Nijs M. Cryostorage management of reproductive cells and tissues in ART: status, needs, opportunities, and potential new challenges. 2023.DOI:    
4668/0/10.1016/j.rbmo.2023.06.007   View
Costa-Borges N, First babies conceived with Automated Intracytoplasmic Sperm Injection. Reprod Biomed Online. 2023 May 25:103237. doi: 10.1016/j.rbmo.2023.05.009    
4667/0/10.1016/j.rbmo.2023.05.009   View
Maged AM, El-Mazny A, Lasheen Y, El-Nassery N. Endometrial scratch injury in infertile women undergoing in vitro fertilization cycles: a systematic review and meta-analysis. J Int Med Res. 2023 Jul,51(7):3000605231175365. doi: 10.1177/03000605231175365    
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Zhang X, Wu S, Qi X, Gao S, Qi J, Zhang S, Tan J. Effect of Paternal Body Mass Index on In Vitro Fertilization and Neonatal Outcomes among Oligozoospermia and Asthenospermia Patients. World J Mens Health. 2023 Jun 20. doi: 10.5534/wjmh.220286    
4665/0/10.5534/wjmh.220286   View
Lu MM, Wen YX, Liu YL, Ding CH, Zhou CQ, Xu YW. Trophectoderm biopsy reduces the level of serum β,,-human chorionic gonadotropin in early pregnancy. Fertil Steril. 2020 Oct,114(4):801-808. doi: 10.1016/j.fertnstert.2020.05.015    
4664/0/10.1016/j.fertnstert.2020.05.015   View
Gordon CE, Racowsky C. Trophectoderm biopsy-perhaps not such a benign intervention. Fertil Steril. 2020 Oct,114(4):748-749. doi: 10.1016/j.fertnstert.2020.06.027    
4663/0/10.1016/j.fertnstert.2020.06.027   View
Makhijani R, Bartels CB, Godiwala P, Bartolucci A, DiLuigi A, Nulsen J, Grow D, Benadiva C, Engmann L. Impact of trophectoderm biopsy on obstetric and perinatal outcomes following frozen-thawed embryo transfer cycles. Hum Reprod. 2021 Jan 25,36(2):340-348. doi: 10.1093/humrep/deaa316. PMID: 33313768.    
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Lu MM, Wen YX, Liu YL, Ding CH, Zhou CQ, Xu YW. Trophectoderm biopsy reduces the level of serum β,,-human chorionic gonadotropin in early pregnancy. Fertil Steril. 2020 Oct,114(4):801-808. doi: 10.1016/j.fertnstert.2020.05.015. Epub 2020 Jul 31. PMID: 32741620.    
4661/0/10.1016/j.fertnstert.2020.05.015   View
Özdamar Ö, Boynukalin FK, Gültomruk M, Yarkiner Z, Findikli N, Bahceci M. Impact of trophoectoderm biopsy for preimplantation genetic testing on serum β,,-hCG levels, time of delivery and birthweight following frozen embryo transfer cycles. Gynecol Endocrinol. 2023 Dec,39(1):2227278. doi: 10.1080/09513590.2023.2227278    
4660/0/10.1080/09513590.2023.2227278   View
Elad D, Jaffa AJ, Grisaru D. Biomechanics of Early Life in the Female Reproductive Tract. Physiology (Bethesda). 2020 Mar 1,35(2):134-143. doi: 10.1152/physiol.00028.2019    
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Muter J, Lynch VJ, McCoy RC, Brosens JJ. Human embryo implantation. Development. 2023 May 15,150(10):dev201507. doi: 10.1242/dev.201507. Epub 2023 May 31. PMID: 37254877, PMCID: PMC10281521.    
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Rossant J, Tam PP. Blastocyst lineage formation, early embryonic asymmetries and axis patterning in the mouse. Development. 2009 Mar,136(5):701-13. doi: 10.1242/dev.017178    
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Hawdon A, Geoghegan ND, Mohenska M, Elsenhans A, Ferguson C, Polo JM, Parton RG, Zenker J. Apicobasal RNA asymmetries regulate cell fate in the early mouse embryo. Nat Commun. 2023 May 30,14(1):2909. doi: 10.1038/s41467-023-38436-2    
4656/0/10.1038/s41467-023-38436-2   View
Professor Kirkman-Brown, Mechanistic analysis of sperm selection with hyaluronic acid and treatment outcomes,    
4655//   View
Asserhřj LL, Mizrak I, Heldarskard GF, Clausen TD, Hoffmann ER, Greisen G, Main KM, Madsen PL, Jensen RB, Pinborg A. Childhood BMI after ART with frozen embryo transfer. Hum Reprod. 2023 Jun 22:dead127. doi: 10.1093/humrep/dead127    
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Wang F, Wang Q, Song Y, Ding J, Li H, Meng Q. Programmed frozen embryo transfer cycles are associated with a higher risk of abnormal placental development: a retrospective cohort study of singleton live births. Front Endocrinol (Lausanne). 2023 Jun 6,14:1202044. doi: 10.3389/fendo.2023.1202044    
4653/0/10.3389/fendo.2023.1202044   View
Fancsovits P, Lehner A, Kaszas Z, Nemes A, Dudas B, Joo K, Murber A, Berkes-Bara E, Fekecs G, Urbancsek J. Intracytoplasmic sperm injection does not improve the outcome of IVF treatments in patients with advanced maternal age or low oocyte number: a randomized controlled trial. J Gynecol Obstet Hum Reprod. 2023 Jun 20:102625. doi: 10.1016/j.jogoh.2023.102625    
4652/0/10.1016/j.jogoh.2023.102625   View
Jayaprakasan K, Walker KF, Clewes JS, Johnson IR, Raine-Fenning NJ. The interobserver reliability of off-line antral follicle counts made from stored three-dimensional ultrasound data: a comparative study of different measurement techniques. Ultrasound Obstet Gynecol. 2007 Mar,29(3):335-41. doi: 10.1002/uog.3913    
4651/0/10.1002/uog.3913   View
Kyprianou MA, Dakou K, Lainas GT, Xenariou M, Makris A, Lainas TG. Two-dimensional ultrasound results in underestimation of the ovarian follicle size compared to automated three-dimensional imaging in women undergoing IVF. J Ultrasound. 2023 Jun 23. doi: 10.1007/s40477-023-00797-1    
4650/0/10.1007/s40477-023-00797-1   View
University College London. "One in five women become pregnant naturally after having a baby conceived with IVF." ScienceDaily. ScienceDaily, 21 June 2023.    
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LIfe Whisperer. FujiFilm.    
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Diakiw SM, Hall JMM, VerMilyea MD, Amin J, Aizpurua J, Giardini L, Briones YG, Lim AYX, Dakka MA, Nguyen TV, Perugini D, Perugini M. Development of an artificial intelligence model for predicting the likelihood of human embryo euploidy based on blastocyst images from multiple imaging systems during IVF. Hum Reprod. 2022 Jul 30,37(8):1746-1759. doi: 10.1093/humrep/deac131    
4647/0/10.1093/humrep/deac131   View
Diakiw SM, Hall JMM, VerMilyea MD, Amin J, Aizpurua J, Giardini L, Briones YG, Lim AYX, Dakka MA, Nguyen TV, Perugini D, Perugini M. Development of an artificial intelligence model for predicting the likelihood of human embryo euploidy based on blastocyst images from multiple imaging systems during IVF. Hum Reprod. 2022 Jul 30,37(8):1746-1759. doi: 10.1093/humrep/deac131    
4646/0/10.1093/humrep/deac131   View
Diakiw SM, Hall JMM, VerMilyea M, Lim AYX, Quangkananurug W, Chanchamroen S, Bankowski B, Stones R, Storr A, Miller A, Adaniya G, van Tol R, Hanson R, Aizpurua J, Giardini L, Johnston A, Van Nguyen T, Dakka MA, Perugini D, Perugini M. An artificial intelligence model correlated with morphological and genetic features of blastocyst quality improves ranking of viable embryos. Reprod Biomed Online. 2    
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Prof. David K Gardner, Oct 1, 2020. Lactate and Embryos – a new perspective.    
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Asgari F, Gavahi A, Karimi M, Vatannejad A, Amjadi F, Aflatoonian R, Zandieh Z. Risk of embryo aneuploidy is affected by the increase in sperm DNA damage in recurrent implantation failure patients under ICSI-CGH array cycles. Hum Fertil (Camb). 2022 Dec,25(5):872-880. doi: 10.1080/14647273.2021.1920054    
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Ping P, Liu Y, Zheng Z, Ma Y, Dong F, Chen X. Association of embryo aneuploidy and sperm DNA damage in unexplained recurrent implantation failure patients under NGS-based PGT-A cycles. Arch Gynecol Obstet. 2023 Jun 21. doi: 10.1007/s00404-023-07098-2    
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Gardner DK. Lactate production by the mammalian blastocyst: manipulating the microenvironment for uterine implantation and invasion? Bioessays. 2015 Apr,37(4):364-71. doi: 10.1002/bies.201400155    
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Gurner KH, Evans J, Hutchison JC, Harvey AJ, Gardner DK. A microenvironment of high lactate and low pH created by the blastocyst promotes endometrial receptivity and implantation. Reprod Biomed Online. 2022 Jan,44(1):14-26. doi: 10.1016/j.rbmo.2021.09.012    
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PROFESSOR DAVID K. GARDNER, The curious case of lactate, a blastocyst and an endometrium,    
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Arce JC, Larsson P, García-Velasco JA. Establishing the follitropin delta dose that provides a comparable ovarian response to 150 IU/day follitropin alfa. Reprod Biomed Online. 2020 Oct,41(4):616-622. doi: 10.1016/j.rbmo.2020.07.006    
4638/0/10.1016/j.rbmo.2020.07.006   View
Lispi M, Humaidan P, Bousfield GR, D'Hooghe T, Ulloa-Aguirre A. Follicle-Stimulating Hormone Biological Products: Does Potency Predict Clinical Efficacy? Int J Mol Sci. 2023 May 19,24(10):9020. doi: 10.3390/ijms24109020. PMID: 37240364, PMCID: PMC10218858.    
4637/0/10.3390/ijms24109020   View
Thwaites A, Hall J, Barrett G, Stephenson J. Contraception after in vitro fertilisation (IVF): a qualitative study of the views of women who have had spontaneous pregnancies after successful IVF. Reprod Health. 2022 Feb 8,19(1):40. doi: 10.1186/s12978-022-01349-2    
4636/0/10.1186/s12978-022-01349-2   View
Thwaites A, Hall J, Barrett G, Stephenson J. How common is natural conception in women who have had a livebirth via assisted reproductive technology? Systematic review and meta-analysis. Hum Reprod. 2023 Jun 20:dead121. doi: 10.1093/humrep/dead121    
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Johan Sterckx and others, Electronic witnessing in the medically assisted reproduction laboratory: insights and considerations after 10 years of use, Human Reproduction, 2023,, dead115,    
4634/0/10.1093/humrep/dead115   View
Tanya Samarasekera,Elissa Willats,Mark P. Green,Tristan Hardy,Luk Rombauts, Deirdre Zander-Fox. Impact of male age on paternally derived embryonic aneuploidy: a retrospective cohort study of SNP-microarray outcomes following blastocyst biopsy. (2023) RBMO.    
4633/0/10.1016/j.rbmo.2023.06.002   View
Mina Alikani. The success of ICSIA and the tough road to automation. (2023). RBMO.    
4632/0/10.1016/j.rbmo.2023.06.001   View
Nuno Costa-Borges, (2023). First babies conceived with automated ICSI (ICSIA). RBMO.    
4631/0/10.1016/j.rbmo.2023.05.009   View
Vallet-Buisan M, Mecca R, Jones C, Coward K, Yeste M. Contribution of semen to early embryo development: fertilization and beyond. Hum Reprod Update. 2023 Mar 7:dmad006. doi: 10.1093/humupd/dmad006    
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Monteleone P, Giovanni Artini P, Simi G, Casarosa E, Cela V, Genazzani AR. Follicular fluid VEGF levels directly correlate with perifollicular blood flow in normoresponder patients undergoing IVF. J Assist Reprod Genet. 2008 May,25(5):183-6. doi: 10.1007/s10815-008-9218-1. Epub 2008 May 1. PMID: 18449636, PMCID: PMC2582064.    
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Monteleone P, Giovanni Artini P, Simi G, Casarosa E, Cela V, Genazzani AR. Follicular fluid VEGF levels directly correlate with perifollicular blood flow in normoresponder patients undergoing IVF. J Assist Reprod Genet. 2008 May,25(5):183-6. doi: 10.1007/s10815-008-9218-1    
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Wu WB, Chen HT, Lin JJ, Lai TH. VEGF Concentration in a Preovulatory Leading Follicle Relates to Ovarian Reserve and Oocyte Maturation during Ovarian Stimulation with GnRH Antagonist Protocol in In Vitro Fertilization Cycle. J Clin Med. 2021 Oct 28,10(21):5032. doi: 10.3390/jcm10215032    
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Rinehart LA. Storage, transport, and disposition of gametes and embryos: legal issues and practical considerations. Fertil Steril. 2021 Feb,115(2):274-281. doi: 10.1016/j.fertnstert.2020.11.025    
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Pellegrini L, De Angelis F, Tartaglia S, Toschi M, Galliano D, Pellicer A, Cozzolino M. The international transportation of frozen embryos does not affect IVF outcomes. Arch Gynecol Obstet. 2023 Jun 15. doi: 10.1007/s00404-023-07092-8    
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Bayefsky MJ, Shaw J, Hamer D, Martel R, Reich J, Blakemore JK. A balancing act: sex selection after pre-implantation genetic testing for aneuploidy for first versus second baby. Hum Reprod. 2023 May 19:dead101. doi: 10.1093/humrep/dead101    
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Tesarik J, Mendoza-Tesarik R. Cyclic Adenosine Monophosphate: A Central Player in Gamete Development and Fertilization, and Possible Target for Infertility Therapies. Int J Mol Sci. 2022 Dec 1,23(23):15068. doi: 10.3390/ijms232315068    
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Tesarik J, Mendoza-Tesarik R. Molecular Clues to Understanding Causes of Human-Assisted Reproduction Treatment Failures and Possible Treatment Options. Int J Mol Sci. 2022 Sep 8,23(18):10357. doi: 10.3390/ijms231810357    
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