- Created on 9/04/2019 5:44:46 PM
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A familial case report of a 13:22 chromosomal translocation with recurrent intracytoplasmic sperm injection failure
We propose the involvement of a balanced t(13:22)(q21.2:q13.3) chromosomal translocation in the pathogenesis of recurrent ART or spontaneous reproductive failures. Hence, it is suggested that all cases with structural chromosomal abnormalities be counseled prior to opting for ART and undergoing pre-implantation genetic diagnosis (PGD).
When my grandchildren in the future ask: ‘Grandad, did you know what you were doing when you worked in the IVF lab?’. The answer is not that easy: I did my best and we helped a lot of children to be conceived, but our databases were less than perfect and we essentially did not know what we exposed gametes and embryos to as the formulation of different culture media was kept secret to us.
The health of children conceived by ART: ‘the chicken or the egg?’
However, studies including children of subfertile couples or of couples treated with milder fertility treatments, such as IUI, as controls show that perinatal risks in these cohorts are lower than for ART children but still higher than for SC indicating that both subfertility and ART influence the future outcome.
Spermatogonial stem cells: updates from specification to clinical relevance
This review provides an update including novel views on various aspects of spermatogonial biology (from embryonic to adult stages). We consider this review relevant for all research scientists and clinicians dealing with fertility, spermatogenesis and fertility preservation.
Improved in vitro fertilization success and pregnancy outcome with autologous platelet-rich plasma treatment in unexplained infertility patients that
We observed that, endometrial thickness was higher after 48 :hours from PRP when compared to endometrial thickness before PRP (10 :mm vs. 6.25 :mm, p :< :.001). Clinical pregnancy rate, and importantly live birth rate were also significantly higher in PRP group than the control group. Based on this information, we showed that intrauterine autologous PRP infusion is a safe, inexpensive adjuvant treatment for optimizing end
The impact of adding hp-hMG in r-FSH started GnRH antagonist cycles on ART outcome
In r-FSH :+ :hp-hMG group, significantly higher implantation rates (35.3% vs 24.3%, p=.017), CPRs (51.2% vs 35.8%, p=.015) and lower OHSS rates (1.6% vs 7.4%, p := :.03) were observed respectively compared to r-FSH only treated patients. In conclusion, addition of hp-hMG on the day of antagonist initiation might increase CPRs. A better endometrial receptivity associated with higher implantation rates might be achieved due to h
Time-lapse videography for embryo selection/de-selection: a bright future or fading star?
In this commentary issues identified in time-lapse embryo selection/de-selection algorithms, such as quantitative versus qualitative parameters, are discussed alongside the reference start point for the timing system, and types of datasets used for developing and validating time-lapse algorithms. Considering these factors, alternative future research directions which could potentially solve current issues are proposed.
Which embryo selection method should be offered to the patients?
We have tools that may change the order in which the embryos are transferred but these technologies will not improve the outcome per treatment started. However, they are likely to lead to live birth sooner and may lower the risk of spontaneous abortion. This comes at the risk of potentially losing a small proportion of embryos along with the possibility of additional financial expenses. We should only offer these add on technologies after proper
Interpregnancy interval and singleton pregnancy outcomes after frozen embryo transfer
Conclusion(s): In this nationally representative population, an interval from delivery to start of an FET cycle of <12 months is associated with increased odds for preterm delivery among singleton live births. Consistent with data for patients undergoing fresh IVF, the data support delaying FET 12 months from a live birth.