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Key Points



niPGT-A - non-invasive preimplantation genetic testing+ - Course ID:172 PGD/PGS/Genetics
Codes
SEP82 [865] [LTID:82]
Comment
Non-invasive preimplantation genetic testing involves testing the spent culture medium that blastocysts were culture in for the presence of aneupolidy. Some doubt exists over whether such technology can replace trophectoderm biopsy.
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References related to niPGT-A - non-invasive preimplantation genetic tes -[11] [Ref=12]
Huang L, Bogale B, Tang Y, Lu S, Xie XS, Racowsky C. (2019) Noninvasive preimplantation genetic testing for aneuploidy in spent medium may be more reliable than trophectoderm biopsy. Proc Natl Acad Sci U S A. 2019 Jun 24. pii: 201907472. doi: 10.1073/pnas.1907472116 ID:2237
DOI:10.1073/pnas.1907472116 0 0 0 True 0 8188 0 Last edited on 26/8/2021
Rubio C, Navarro-Sánchez L, García-Pascual CM, Ocali O, Cimadomo D, Venier W, Barroso G, Kopcow L, Bahçeci M, Roos Kulmann MI, López L, De la Fuente E, Navarro R, Valbuena D, Sakkas D, Rienzi L, Simón C. (2020) Multicenter prospective study of concordance between embryo cell-free DNA and trophectoderm biopsies from 1,301 human blastocysts. Am J Obstet Gynecol. 2020 May 6:S0002-9378(20)30520-2. doi: 10.1016/j.ajog.2020.04.035 ID:2463
DOI: 0 0 0 0 8528 Last edited on
Shitara A, Takahashi K, Goto M, Takahashi H, Iwasawa T, Onodera Y, Makino K, Miura H, Shirasawa H, Sato W, Kumazawa Y, Terada Y. Cell-free DNA in spent culture medium effectively reflects the chromosomal status of embryos following culturing beyond implantation compared to trophectoderm biopsy. PLoS One. 2021 Feb 11,16(2):e0246438. doi: 10.1371/journal.pone.0246438 ID:3194
DOI:10.1371/journal.pone.0246438 0 0 0 0 8887 2021 Last edited on 25/2/2021
Babariya D, Leaver M, Wells D. Divining the genetic status of embryos: consult the medium? Fertil Steril. 2019 Sep,112(3):471-473. doi: 10.1016/j.fertnstert.2019.06.012 ID:3212
DOI:10.1016/j.fertnstert.2019.06.012 1311 0 0 True 0 0 2019 Last edited on 16/3/2021
Hanson BM, Tao X, Hong KH, Comito CE, Pangasnan R, Seli E, Jalas C, Scott RT Jr. Noninvasive preimplantation genetic testing for aneuploidy exhibits high rates of deoxyribonucleic acid amplification failure and poor correlation with results obtained using trophectoderm biopsy. Fertil Steril. 2021 Mar 18:S0015-0282(21)00050-9. doi: 10.1016/j.fertnstert.2021.01.028 ID:3229
DOI:10.1016/j.fertnstert.2021.01.028 0 0 0 False 0 8902 2021 Last edited on 23/3/2021
Gombos K, Gálik B, Kalács KI, Gödöny K, Várnagy Á, Alpár D, Bódis J, Gyenesei A, Kovács GL. NGS-Based Application for Routine Non-Invasive Pre-Implantation Genetic Assessment in IVF. Int J Mol Sci. 2021 Feb 28,22(5):2443. doi: 10.3390/ijms22052443 ID:3265
DOI:10.3390/ijms22052443 1311 0 0 True 0 0 2021 Last edited on 12/4/2021
Aizer A, Harel-Inbar N, Shani H, Orvieto R. Can expelled cells/debris from a developing embryo be used for PGT? J Ovarian Res. 2021 Aug 11,14(1):104. doi: 10.1186/s13048-021-00853-6. ID:3639
DOI:10.1186/s13048-021-00853-6 0 0 0 True 0 0 2021 Last edited on 26/8/2021
Kimelman D, Pavone ME. Non-invasive prenatal testing in the context of IVF and PGT-A. Best Pract Res Clin Obstet Gynaecol. 2021 Jan,70:51-62. doi: 10.1016/j.bpobgyn.2020.07.004 ID:3907
DOI:10.1016/j.bpobgyn.2020.07.004 0 0 0 True 0 0 2021 Last edited on 11/8/2021
Leaver M, Wells D. Non-invasive preimplantation genetic testing (niPGT): the next revolution in reproductive genetics? Hum Reprod Update. 2020 Jan 1,26(1):16-42. doi: 10.1093/humupd/dmz033 ID:3908
DOI:10.1093/humupd/dmz033 0 0 0 True 0 0 2020 Last edited on 11/8/2021
Rubio C, Simón C. Noninvasive preimplantation genetic testing for aneuploidy: Is the glass half-empty or half-full? Fertil Steril. 2021 Jun,115(6):1426-1427. doi: 10.1016/j.fertnstert.2021.04.002 ID:3909
DOI:10.1016/j.fertnstert.2021.04.002 0 0 0 True 0 0 2021 Last edited on 11/8/2021
Rubio C, Racowsky C, Barad DH, Scott RT Jr, Simon C. Noninvasive preimplantation genetic testing for aneuploidy in spent culture medium as a substitute for trophectoderm biopsy. Fertil Steril. 2021 Apr,115(4):841-849. doi: 10.1016/j.fertnstert.2021.02.045 ID:3910
DOI:10.1016/j.fertnstert.2021.02.045 0 0 0 False 0 0 2021 Last edited on 8/11/2021
Esmaeilivand M, Fattahi A, Abedelahi A, Hamdi K, Farzadi L, Goharitaban S, Niknafs B. microRNAs in the blastocoel fluid as accessible indicators of chromosomal normality. Reprod Biol. 2022 Sep 5,22(4):100695. doi: 10.1016/j.repbio.2022.100695 ID:4535
DOI:10.1016/j.repbio.2022.100695 0 0 0 False 0 0 2022 Last edited on 12/9/2022

Additional References related to niPGT-A - non-invasive preimplantation genetic tes - [1]

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