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  CCR5-∆:32 is deleterious in the homozygous state in humans
  We use the genotyping and death register information of 409,693 individuals of British ancestry to investigate fitness effects of the CCR5-∆:32 mutation. We estimate a 21% increase in the all-cause mortality rate in individuals who are homozygous for the ∆:32 allele. A deleterious effect of the ∆:32/∆:32 mutation is also independently supported by a significant deviation from the Hardy–Weinberg equilibrium (HWE) due to a defic
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